News

EARO Review (2020 – 2022) – A Review of EARO’s first 3 years

EARO turns 3 this year! To mark this occasion, we are excited to share the EARO Review (2020-2022)! EDDC launched EARO (the EDDC Academic Research Organisation) as a service initiative in mid-2020. The goal was to enable early-stage drug discovery in Singapore by creating multiple pathways for the local academic and biotech community to access […]

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First Patient Dosed in Phase 1 trial of Antibody-Drug Conjugate EBC-129 in Patients with Solid Tumours

The Experimental Drug Development Centre (EDDC), Singapore’s national platform for drug discovery and development, is pleased to share that a first patient has been dosed at the National Cancer Centre Singapore (NCCS) in the first-in-human trial of EBC-129.

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First Made-in-Singapore Antibody-Drug Conjugate (ADC) Approved to Enter Clinical Trials

Approval has been obtained from the U.S. Food and Drug Administration (FDA) to conduct the first-in-human trial for EBC-129 in patients with solid tumours EBC-129 is the first made-in-Singapore antibody-drug conjugate (ADC) that is entering clinical development. It is able to selectively target cancer cells across a range of solid tumours. The ADC and the

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XtalPi and EDDC collaborate in AI-empowered drug discovery program for Non-Small Cell Lung Cancer

XtalPi joins hands with Singapore’s national platform for drug discovery and development to discover more effective treatment options for cancer patients worldwide. In this collaboration, XtalPi will leverage its quantum physics and AI-driven platform, while EDDC provides valuable insight and data on the novel NSCLC target, to accelerate the drug discovery process and propel the

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Computational Chemistry: Virtual screening and drug discovery

Virtual screening involves the use of in silico methods to screen for potential small molecule binders of a target protein. This process usually starts with computationally docking a virtual library of chemical compounds to assess how the compounds interact with a defined binding site on the target protein. This is followed by scoring to predict

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Minister for Trade and Industry, Mr Gan Kim Yong, visits EDDC

Minister for Trade and Industry, Mr Gan Kim Yong, creating an entry on the computer to insert a 384-well plate into the compound store at EDDC’s High Throughput Screening (HTS) facility.On 19 August 2022, Experimental Drug Development Centre (EDDC) hosted a visit by Minister for Trade and Industry, Mr Gan Kim Yong. This visit was

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Compounds against Tuberculosis developed by EDDC and NTU out-licensed to Neuro-Horizon Pharma

The World Health Organisation1 estimates that over 1.5 million people die from tuberculosis (TB) worldwide, making it the second leading infectious disease killer after COVID-19. Caused by the bacterium Mycobacterium tuberculosis, TB is an infectious disease that has plagued humankind for more than 70,000 years2, with an estimated 10 million new cases of TB annually.

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Made-In-Singapore Cancer Drug ETC-159 Advances In Clinical Trials

EDDC’s Biomarker team analysing samples from ETC-159 trialA made-in-Singapore cancer drug, ETC-159, has advanced into the dose expansion portion of its Phase 1B clinical trial. The Phase 1B dose expansion study tests the preliminary efficacy and safety of ETC-159 in a subset of genetically defined patients with microsatellite stable (MSS)1 cancers. MSS tumours have few

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