The EDDC-DB Structural Biology Team combines advanced technologies and experienced scientists to lead research on both druggable and traditionally undruggable targets. Our integrated pipeline supports all stages of discovery, from molecular characterization to high-resolution structure determination and mechanism-of-action studies.

High-Throughput Protein Expression & Purification
We produce recombinant proteins across bacterial, insect, and mammalian systems, optimizing challenging targets such as membrane proteins and multi-domain complexes for high-quality structural and functional studies.

Nuclear Magnetic Resonance (NMR) Spectroscopy
NMR enables ligand and small-molecule structure determination, interaction screening, and dynamic process analysis, complementing crystallography and Cryo-EM.

X-ray Crystallography
Our high-throughput crystallography workflow delivers atomic-resolution structures of proteins and complexes, supporting hit-to-lead optimization, structure-guided design, and fragment-based screening. Specialized methods allow us to tackle challenging targets.

Cryo-Electron Microscopy (Cryo-EM)
Cryo-EM visualizes complex biomolecular assemblies at high resolution, supporting structural studies and screening of small molecules, fragments, and molecular glues in native-like environments.

Biophysical Characterization
We employ Biolayer Interferometry (BLI), Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), and Differential Scanning Fluorimetry (DSF)/Thermal Shift (TS), and related methods to quantify protein stability, binding affinity, and interaction kinetics, validating hits and guiding lead optimization.

By integrating structural, biochemical, and biophysical data, our workflow enables rational drug design, fragment-based discovery, and targeting of challenging protein interfaces—unlocking therapeutic possibilities for even the most complex targets