Our Capabilities

Biologics-related Assay Development

The team’s area of expertise is in large molecule (biologics) related assays, paired with real-time high throughput phenomics (HTP) analyses. This includes cell-based functional assay development and characterization of therapeutic candidates. To achieve efficient workflows, this team’s scientists have established a suite of toolbox assays to evaluate the functionality of antibody-based therapeutics using state-of-the-art instruments.
Established assays include:
  1. Antibody-dependent NK/T-cell mediated cytotoxicity – 2D and 3D co-cultures of tumour and immune cells.
  2. Antibody internalization.
  3. Immuno-profiling and cancer cell surface antigen quantitation.
  4. Colorimetric-based reporter cell line assays.

Routine molecular and cell biology techniques: Molecular cloning, RT-qPCR, ELISA, Western blot, Mammalian tissue culture, RNAi and CRISPR.

Areas of interest:
  • Immuno-oncology
  • Autoimmunity/Chronic inflammatory diseases
  • Fibrosis.
State-of-the-art instruments:
  • NovoCyte Penteon multi-colour flow cytometer
  • xCELLigence RCTA MP quantitative real-time cell analysis system
  • Incucyte SX5 live-cell imaging analysis system