The Antibody Design team focuses on developing novel engineered antibodies for applications in different diseases or treatment modalities. They are interested in amino acid sequences, and how their vast diversity and patterns can govern protein function and structure. Protein sequences, similar to biological grammar and syntax, can be used to inform the design of new proteins with improved functions and properties.
To make the design of proteins with unique properties more efficient, the team takes an integrated design approach from in-silico methods coupled with data-driven tuning, to empirical strategies for optimization and validation.
They also work with different domain experts through collaboration or cross-function matrix, who share the inspiration in tackling biomedical and biological problems.